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1-(2,4-Xylyl)piperazine → 1-(2,4-dimethylphenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propanal | HCID 86639918 | — |
| 生成物 | 1-(2,4-dimethylphenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine | HCID 25065659 | — |
反応手順
113 mg (82%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propanal (80 mg, 0.276 mmol), 1-(2,4-dimethylphenyl)piperazine (53 mg, 0.276 mmol), DIPEA (0.072 mL, 0.414 mmol) and NaBH(OAc)3 (175 mg, 0.828 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08372844B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-012071c9e55340adad600d5b3e1f8b4d |
| 出典メモ | uspto-grants-2013_02 |