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1-Phenylpiperazine → 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-phenylpiperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Phenylpiperazine | HCID 7096 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal | HCID 86639930 | — |
| 生成物 | 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-phenylpiperazine | HCID 68557517 | — |
反応手順
132 mg (73%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal (100 mg, 0.450 mmol), 1-phenylpiperazine (0.067 mL, 0.450 mmol), DIPEA (0.118 mL, 0.675 mmol) and NaBH(OAc)3 (286 mg, 1.350 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08372844B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-8668a488c358456ba973da6facd6dcb2 |
| 出典メモ | uspto-grants-2013_02 |