Oxiranemethanol, 4-methylbenzenesulfonate, (S)- → 4-(4-amino-3-chlorophenoxy)-6-cyano-7-((2S)-oxiran-2-yl)methoxyquinoline

HRID 387908

反応式

HRID 387908 の反応式
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([OH:19])=[C:14]([C:17]#[N:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[CH:4][C:3]=1[Cl:22].CC1C=CC(S(O[CH2:34][C@@H:35]2[CH2:37][O:36]2)(=O)=O)=CC=1>>[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:19][CH2:34][C@@H:35]4[CH2:37][O:36]4)=[C:14]([C:17]#[N:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[CH:4][C:3]=1[Cl:22]

参加物

3

反応物 2

HCID 153296Oxiranemethanol, 4-methylbenzenesulfonate, (S)-HCID 1358293874-(4-Amino-3-chlorophenoxy)-6-cyano-7-hydroxyquinoline

生成物 1

HCID 865914684-(4-amino-3-chlorophenoxy)-6-cyano-7-((2S)-oxiran-2-yl)methoxyquinoline収率 12.5%

実験手順

The title compound (147 mg, 0.400 mmol, 12.5%) was obtained as light brown crystals from a 4-(4-amino-3-chlorophenoxy)-6-cyano-7-hydroxyquinoline crude product (1.00 g, 3.21 mmol) and (2S)-oxiran-2-ylmethyl 4-methyl-1-benzene sulfonate, by the same procedure as in Example 7.

出典と根拠

ORDレコード
ord-adeec8a5010846da8bd8e69b3c5903a4
出典データセット
uspto-grants-2013_02
特許番号
US08372981B2

関連ノート

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