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4-Nitrophenol → 2-[(Cyclopropylmethyl)aminocarbonyl]-4-(4-nitrophenoxy)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrophenol | HCID 980 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-Chloro-2-[(cyclopropylmethyl)aminocarbonyl]pyridine | HCID 34829121 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-[(Cyclopropylmethyl)aminocarbonyl]-4-(4-nitrophenoxy)pyridine | HCID 22936897 | — |
反応手順
4-Chloro-2-[(cyclopropylmethyl)aminocarbonyl]pyridine (1.5 g), p-nitrophenol (2.0 g), Hunig's base (3.1 ml) and 1-methyl-2-pyrrolidinone (6.2 ml) were stirred together at 160° C. for 3 hours. Water was added, extraction was performed with ethyl acetate, and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography (hexane:ethyl acetate=4:1, followed by 2:1) using NH type silica gel to obtain 0.35 g of the target substance as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08372981B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-fbad9ecfc476424d8f3a34685d7a0d78 |
| 出典メモ | uspto-grants-2013_02 |