1H-Benzotriazole-1-methanol → N-{1-(1H-Benzotriazolyl)methyl}-4-benzyloxy-2-fluoroaniline

HRID 388021

反応式

HRID 388021 の反応式
[CH2:1]([O:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([F:16])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:17]1([CH2:26]O)[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1>CO>[N:17]1([CH2:26][NH:13][C:12]2[CH:14]=[CH:15][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][C:11]=2[F:16])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1

参加物

4

反応物 2

HCID 2241691H-Benzotriazole-1-methanolHCID 114998094-(Benzyloxy)-2-fluoroaniline

生成物 1

HCID 22936313N-{1-(1H-Benzotriazolyl)methyl}-4-benzyloxy-2-fluoroaniline収率 66.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

After dissolving 4-benzyloxy-2-fluoroaniline (11.25 g, 51.78 mmol) in methanol (300 ml), 1H-benzotriazole-1-methanol (8.11 g, 54.37 mmol) was added and the mixture was stirred for 10 hours at room temperature. The precipitated crystals were filtered out, washed with ethanol and dried by aspiration to obtain the title compound (12.01 g, 34.47 mmol, 66.57%) as colorless crystals.

後処理

  1. additionwas added
  2. filtrationThe precipitated crystals were filtered out
  3. washwashed with ethanol
  4. customdried by aspiration

出典と根拠

ORDレコード
ord-cc5446e4087a46568ebdea5815b005e6
出典データセット
uspto-grants-2013_02
特許番号
US08372981B2

関連ノート

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