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Water → N-[4-(7-benzyloxy-6-cyanoquinolin-4-yloxy)-2,3-dimethylphenyl]-N'-cyclopropylurea

HRID 388067
ノート
印刷プレビュー

反応式

HRID 388067 の反応式
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.CN(C)C=O.C1([O:16][C:17](=O)[NH:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26]3[C:35]4[C:30](=[CH:31][C:32]([O:38][CH2:39][C:40]5[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=5)=[C:33]([C:36]#[N:37])[CH:34]=4)[N:29]=[CH:28][CH:27]=3)=[C:21]([CH3:46])[C:20]=2[CH3:47])C=CC=CC=1.O>C(OCC)(=O)C>[CH2:39]([O:38][C:32]1[CH:31]=[C:30]2[C:35]([C:26]([O:25][C:22]3[CH:23]=[CH:24][C:19]([NH:18][C:17]([NH:4][CH:1]4[CH2:3][CH2:2]4)=[O:16])=[C:20]([CH3:47])[C:21]=3[CH3:46])=[CH:27][CH:28]=[N:29]2)=[CH:34][C:33]=1[C:36]#[N:37])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 962WaterHCID 6228DimethylformamideHCID 69828CyclopropylamineHCID 67201413(4-(7-Benzyloxy-6-cyano-quinolin-4-yloxy)-2,3-dimethylphenyl)carbamic acid phenyl ester

生成物 1

HCID 22936500N-[4-(7-benzyloxy-6-cyanoquinolin-4-yloxy)-2,3-dimethylphenyl]-N'-cyclopropylurea

試薬・触媒・溶媒 1

HCID 8857
Ethyl Acetate
溶媒

実験手順

Cyclopropylamine (1 ml) was added to dimethylformamide (10 ml), and then (4-(7-benzyloxy-6-cyano-quinolin-4-yloxy)-2,3-dimethylphenyl)carbamic acid phenyl ester (1.99 g) was added thereto and the mixture was stirred at room temperature for 10 minutes. Water (30 ml) and ethyl acetate (30 ml) were added, and the precipitated crystals were filtered out and washed with ethyl acetate to obtain the title compound (1660 mg).

後処理

  1. filtrationthe precipitated crystals were filtered out
  2. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-14e9412e41cf4d698135c34c8cd13039
出典データセット
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08372981B2

反応ノート

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