2-Methoxypyridine-3,4-diamine → 2-(2-Methoxy-4-methoxycarbonyl-phenyl)-5H-imidazo[4,5-c]pyridin-4-one hydrochloride

HRID 3883ノート

反応式

HRID 3883 の反応式
C[O:2][C:3]1[C:8]([NH2:9])=[C:7]([NH2:10])[CH:6]=[CH:5][N:4]=1.CO[C:13]1[CH:21]=[C:20]([C:22]#N)[CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16].[Cl:24][CH:25](Cl)C.[CH2:28]([OH:30])C>>[ClH:24].[CH3:28][O:30][C:21]1[CH:13]=[C:14]([C:15]([O:17][CH3:25])=[O:16])[CH:18]=[CH:19][C:20]=1[C:22]1[N:9]=[C:8]2[C:3](=[O:2])[NH:4][CH2:5][CH:6]=[C:7]2[N:10]=1

参加物

4

反応物 3

HCID 101489982-Methoxypyridine-3,4-diamineHCID 151660044-Cyano-2-methoxybenzoic acidHCID 18381953Dichloroethane ethanol

生成物 1

HCID 704203902-(2-Methoxy-4-methoxycarbonyl-phenyl)-5H-imidazo[4,5-c]pyridin-4-one hydrochloride

実験手順

Prepared analogously to Example 1 from 2-methoxy-3,4-diaminopyridine and 2-methoxy-4-cyano-benzoic acid. The product mixture obtained is digested with dichloroethane/ethanol (3:1). The undissolved material is filtered off, and the solution is evaporated and boiled with methanolic hydrochloric acid. On cooling, the product crystallizes out in the form of the hydrate.

後処理

  1. customThe product mixture obtained
  2. filtrationThe undissolved material is filtered off
  3. customthe solution is evaporated
  4. temperatureOn cooling
  5. customthe product crystallizes out in the form of the hydrate

出典と根拠

ORDレコード
ord-1bcc2a3d16bb4766b58a295e2fc2fc6b
出典データセット
uspto-grants-1988_02
特許番号
US04722929

反応ノート

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