Carbon tetrabromide → 3-Bromomethyl-4,6-dimethyl-benzo[d]isothiazole
反応式
[CH3:1][C:2]1[C:7]2[C:8]([CH2:11]O)=[N:9][S:10][C:6]=2[CH:5]=[C:4]([CH3:13])[CH:3]=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(Br)(Br)(Br)[Br:34]>C(Cl)Cl>[Br:34][CH2:11][C:8]1[C:7]2[C:2]([CH3:1])=[CH:3][C:4]([CH3:13])=[CH:5][C:6]=2[S:10][N:9]=1参加物
5
実験手順
To a solution of (4,6-dimethyl-1,2-benzisothiazol-3-yl)-methanol (100 mg, 0.5 mmol) in CH2Cl2 (15 mL) are added PPh3 (200 mg, 0.78 mmol) and CBr4 (340 mg, 1 mmol) at room temperature. The solution is stirred at the same temperature for 1 hour. The solution is concentrated and the residue is purified by flash chromatography with 10% EtOAc in Hexane as the eluent to afford 3-bromomethyl-4,6-dimethyl-1,2-benzisothiazole (90 mg, 68%) as a white solid.
後処理
- concentrationThe solution is concentrated
- customthe residue is purified by flash chromatography with 10% EtOAc in Hexane as the eluent
出典と根拠
- ORDレコード
- ord-3cd19692578044dc966e5dc39b0419a9
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08377949B2
反応ノート
読み込み中…