化工社化工社 化学情報印刷レポート · 研究参考用
Water → 1-Benzoyl-3-[1(naphth-1-ylmethyl)piperid-4-yl]urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1-Chloromethylnaphthalene | HCID 6845 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Benzoylureidopiperidine | HCID 12608582 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Benzoyl-3-[1(naphth-1-ylmethyl)piperid-4-yl]urea | HCID 12942301 | — |
反応手順
1-Chloromethylnaphthalene (0.88 g, 0.005 m), 4-benzoylureidopiperidine (1.28 g, 0.005 m) and triethylamine (0.6 g) in dimethylformamide (25 cm3) were stirred at room temperature for 24 hours. Water was added and the precipitated solid filtered off. The solid was suspended in isopropylalcohol and acidified with ethanolic HCl. The title compound was filtered off and dried as the hydrochloride salt, hemihydrate (1.2 g), m.p. 185°-186° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722930 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-6c695e0fc6704fb0ad8fd2c49b74c803 |
| 出典メモ | uspto-grants-1988_02 |