Ammonia → HCID 178508170、化合物

HRID 388616ノート

反応式

HRID 388616 の反応式
[Si]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:25]2[C:24]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[N:18]=[C:17](Cl)[C:16]=2[N:15]=[C:14]1[OH:27])(C(C)(C)C)(C)C.[NH3:28]>CO>[NH2:28][C:17]1[C:16]2[N:15]=[C:14]([OH:27])[N:13]([CH2:12][CH2:11][CH2:10][CH2:9][OH:8])[C:25]=2[C:24]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N:18]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 178455216HCID 178455216、化合物

生成物 1

HCID 178508170HCID 178508170、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
150 °C

実験手順

1-[4-(tert-Butyldimethylsilanyloxy)butyl]-4-chloro-1H-imidazo[4,5-c]quinolin-2-ol (5.0 g, 12 mmol) and ammonia (200 mL of a 7 N solution in methanol) were added to a high-pressure vessel, which was sealed and heated in an oven at 150° C. for five days, allowed to cool, and concentrated under reduced pressure. The crude product was triturated with hexane for 15 minutes, and the resulting solid was isolated by filtration, washed with hexane (500 mL), and dried under vacuum to provide 3.53 g of 4-amino-1-(4-hydroxybutyl)-1H-imidazo[4,5-c]quinolin-2-ol as a light gray solid.

後処理

  1. customwhich was sealed
  2. temperatureto cool
  3. concentrationconcentrated under reduced pressure
  4. customThe crude product was triturated with hexane for 15 minutes
  5. customthe resulting solid was isolated by filtration
  6. washwashed with hexane (500 mL)
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-0794f5e19dc34465b4c1fd33f406e10c
出典データセット
uspto-grants-2013_02
特許番号
US08377957B2

反応ノート

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