HCID 66730327、化合物 → HCID 66730359、化合物

反応式

[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH:9]([O:11][C:12]2[C:21]3[C:16](=[C:17]([CH3:24])[C:18]([O:22][CH3:23])=[CH:19][CH:20]=3)[N:15]=[C:14]([C:25]3[S:26][CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[N:29]=3)[N:13]=2)[CH2:8][CH2:7][N:6]1C)=[O:4].COC(C1CC(OC2C3C(=C(C)C(OC)=CC=3)N=C(C3SC=C(C(F)(F)F)N=3)C=2)CCN1)=O>>[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH:9]([O:11][C:12]2[C:21]3[C:16](=[C:17]([CH3:24])[C:18]([O:22][CH3:23])=[CH:19][CH:20]=3)[N:15]=[C:14]([C:25]3[S:26][CH:27]=[C:28]([C:30]([F:31])([F:32])[F:33])[N:29]=3)[N:13]=2)[CH2:8][CH2:7][NH:6]1)=[O:4]

参加物

反応物 2

HCID 66730327HCID 66730327、化合物

HCID 667303534-[7-Methoxy-8-methyl-2-(4-trifluoromethyl-thiazol-2-yl)-quinolin-4-yloxy]-piperidine-2-carboxylic acid methyl ester

生成物 1

HCID 66730359HCID 66730359、化合物収率 55%

実験手順

Compound 23 was synthesized from compound 22 as a pale yellow powder in 55% yield according to the procedure as described for compound 14. MS (ESI, EI+) m/z=483 (MH+).

出典と根拠

ORDレコード: ord-2ec8e0f8c0ca462c82370ed6804843ed
出典データセット: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08377962B2

反応ノート

読み込み中…