2-Fluoro-4-iodoaniline → 5-Chloro-N-((1-(2-fluoro-4-iodophenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide

HRID 388798ノート

反応式

HRID 388798 の反応式
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][C:11]2[N:12]=[N:13]N(C3C=CC(N4C=CC=CC4=O)=CC=3)[CH:15]=2)=[O:8])=[CH:4][CH:3]=1.[I:29][C:30]1[CH:36]=[CH:35][C:33]([NH2:34])=[C:32]([F:37])[CH:31]=1>>[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][C:11]2[N:12]=[N:13][N:34]([C:33]3[CH:35]=[CH:36][C:30]([I:29])=[CH:31][C:32]=3[F:37])[CH:15]=2)=[O:8])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 1856942-Fluoro-4-iodoanilineHCID 576405055-Chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide

生成物 1

HCID 576407645-Chloro-N-((1-(2-fluoro-4-iodophenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide

実験手順

The title compound was prepared by the same procedure for compound 35 described in Example 290 in Scheme 5, using 4-iodo-2-fluoroaniline in place of 4-iodoaniline. MS found for C14H9ClFIN4OS as (M+H)+ 462.0, 464.0

出典と根拠

ORDレコード
ord-a3649b51cef64e4aae791ee25dd811ad
出典データセット
uspto-grants-2013_02
特許番号
US08377974B2

反応ノート

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