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Benzoyl isothiocyanate → 1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl isothiocyanate | HCID 68284 | — |
| 反応物 | 4-Amino-1-(2-naphthyl)methylpiperidine | HCID 11195823 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea | HCID 12942346 | — |
反応手順
4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoylisothiocyanate (0.69 g, 0.0042 m) in toluene (120 cm3) was stirred at room temperature for 6 hours. The solvent was evaporated and the gum dissolved in isopropyl alcohol and acidified with ethanolic HCl. The solvent was evaporated and the residue dissolved in ethyl acetate. The title compound crystallised and was filtered and dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722930 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-abd517df60204610939cf68a6c24b096 |
| 出典メモ | uspto-grants-1988_02 |