Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 178509213、化合物

HRID 388926

反応式

HRID 388926 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[NH:12][C:11]2[CH:13]=[CH:14][C:15]([C:17]([OH:19])=O)=[CH:16][C:10]=2[N:9]=1.[NH2:20][C:21]1[C:29]2[C:24](=[CH:25][C:26]([NH2:30])=[CH:27][CH:28]=2)[NH:23][N:22]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[NH2:20][C:21]1[C:29]2[C:24](=[CH:25][C:26]([NH:30][C:17]([C:15]3[CH:14]=[CH:13][C:11]4[NH:12][C:8]([NH:7][C:2]5[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=5)=[N:9][C:10]=4[CH:16]=3)=[O:19])=[CH:27][CH:28]=2)[NH:23][N:22]=1

参加物

4

反応物 3

HCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 534153661H-Indazole-3,6-diamineHCID 178524174HCID 178524174、化合物

生成物 1

HCID 178509213HCID 178509213、化合物

実験手順

The carboxylic acid (0.5 mmol) from above was coupled with aforementioned 3,6-diaminoindazole (0.5 mmol) using HBTU as described in general procedure D to afford 2-(pyridin-2-ylamino)-1H-benzimidazole-5-carboxylic acid (3-amino-1H-indazol-6-yl)-amide. MS: m/z 385 (M+H)+.

出典と根拠

ORDレコード
ord-e93b1d8fe3064101a9065ede2dd61697
出典データセット
uspto-grants-2013_02
特許番号
US08377983B2

関連ノート

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