Thiourea → Methyl 2-amino-4-cyclopropyl-1,3-thiazole-5-carboxylate hydrobromide
反応式
[Br:1][CH:2]([C:7]([CH:9]1[CH2:11][CH2:10]1)=O)[C:3]([O:5][CH3:6])=[O:4].[NH2:12][C:13]([NH2:15])=[S:14]>C(O)C>[BrH:1].[NH2:15][C:13]1[S:14][C:2]([C:3]([O:5][CH3:6])=[O:4])=[C:7]([CH:9]2[CH2:11][CH2:10]2)[N:12]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
Methyl 2-bromo-3-cyclopropyl-3-oxopropanoate (3.3 g) and thiourea (900 mg) were dissolved in ethanol (20 ml) followed by stirring at 80° C. overnight. After cooling to room temperature, the solvent was evaporated under reduced pressure, and the residue was washed with isopropanol to obtain, as a grayish white solid, methyl 2-amino-4-cyclopropyl-1,3-thiazole-5-carboxylate monohydrobromide (2.82 g).
後処理
- temperatureAfter cooling to room temperature
- customthe solvent was evaporated under reduced pressure
- washthe residue was washed with isopropanol
出典と根拠
- ORDレコード
- ord-a49b409e4d3f46b592b90b530e6029cf
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08377923B2
反応ノート
読み込み中…