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Pyridine → 1-Benzoyl-1-methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | 1-Methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea | HCID 19762408 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Benzoyl-1-methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea | HCID 12942344 | — |
反応手順
1-Methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea (1.4 g.) (prepared by reacting 4-amino-1-(naphth-2-ylmethyl)piperidine with methyl isocyanate) in toluene (30 cm3) was acylated using benzoyl chloride (0.92 g) in presence of pyridine (0.6 g) to give the title compound: m.p. of HCl, hemihydrate salt =164°-166° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722930 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-eded3f07bc674eab884909ce377e9ea4 |
| 出典メモ | uspto-grants-1988_02 |