4-Toluenesulfonyl chloride → HCID 59287022、化合物

HRID 389210ノート

反応式

HRID 389210 の反応式
[Br:1][C:2]1[CH:3]=[N+:4]([O-])[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2.S(Cl)(C1C=CC(C)=CC=1)(=O)=[O:16]>CCOC(C)=O.C([O-])([O-])=O.[K+].[K+]>[Br:1][C:2]1[C:3](=[O:16])[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2

参加物

5

反応物 2

HCID 73974-Toluenesulfonyl chlorideHCID 592871093-Bromo-7-methoxyquinoline 1-oxide

生成物 1

HCID 59287022HCID 59287022、化合物

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 11430Potassium Carbonate溶媒

実験手順

To a solution of 3-bromo-7-methoxyquinoline 1-oxide (2.04 g, 8.03 mmol) in EtOAc (50 mL) and 15% aqueous K2CO3 (15 mL) at RT, TsCl (1.68 g, 8.83 mmol) was added. The reaction mixture was stirred vigorously at RT for 18 hours, at which time the product was collected by filtration and washed with EtOAc. The solid was dried under vacuum and used with no further purification. LRMS (M+H)+=254.1.

後処理

  1. filtrationwas collected by filtration
  2. washwashed with EtOAc
  3. customThe solid was dried under vacuum
  4. customused with no further purification

出典と根拠

ORDレコード
ord-02a1070da8bb4b269567a34eb3011c5a
出典データセット
uspto-grants-2013_02
特許番号
US08377874B2

反応ノート

読み込み中…