5-Methoxy-2,3,3-trimethyl-3H-indole → 1-(3,5-dinitrobenzyl)-5-methoxy-2,3,3-trimethyl-3H-indolium iodide

HRID 389241

反応式

HRID 389241 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]2([CH3:14])[CH3:13].[N+:15]([C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([N+:26]([O-:28])=[O:27])[CH:25]=1)[CH2:21][I:22])([O-:17])=[O:16]>ClC1C=CC=CC=1Cl>[I-:22].[N+:15]([C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([N+:26]([O-:28])=[O:27])[CH:25]=1)[CH2:21][N+:8]1[C:9]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=2)[C:6]([CH3:14])([CH3:13])[C:7]=1[CH3:12])([O-:17])=[O:16]

参加物

4

反応物 2

HCID 110953925-Methoxy-2,3,3-trimethyl-3H-indoleHCID 226090731-(Iodomethyl)-3,5-dinitrobenzene

生成物 1

HCID 866375401-(3,5-dinitrobenzyl)-5-methoxy-2,3,3-trimethyl-3H-indolium iodide収率 52.5%

試薬・触媒・溶媒 1

HCID 72391,2-Dichlorobenzene溶媒

反応条件

温度
75 °C

実験手順

To 5-methoxy-2,3,3-trimethyl-3H-indole (1.90 g) was added 3,5-dinitrobenzyl iodide (4.62 g) and 1,2-dichlorobenzene (10 ml). The mixture was heated at 75° C. for 3 hours, during which time an orange solid separated. The mixture was then cooled in an ice bath and the solid fraction collected by filtration; it was washed sequentially with dichlorobenzene and diethyl ether and dried under vacuum to give the product (2.62 g).

後処理

  1. customseparated
  2. temperatureThe mixture was then cooled in an ice bath
  3. filtrationthe solid fraction collected by filtration
  4. washit was washed sequentially with dichlorobenzene and diethyl ether
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-586ad7d3615349a1a9ad3d8ba7246df2
出典データセット
uspto-grants-2013_02
特許番号
US08378120B2

関連ノート

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