Water → 4-Hydroxy-5-methyl-2,3-dihydro-1H-inden-1-one

HRID 389312ノート

反応式

HRID 389312 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[O:10][C:9](=[O:12])[CH2:8][CH2:7]2.[Cl-].[Cl-].[Cl-].[Al+3].O>CO>[OH:10][C:11]1[C:2]([CH3:1])=[CH:3][CH:4]=[C:5]2[C:6]=1[CH2:7][CH2:8][C:9]2=[O:12]

参加物

5

反応物 3

HCID 962WaterHCID 6451240Aluminum(III) ChlorideHCID 235130958-Methyl-3,4-dihydrocoumarin

生成物 1

HCID 668122914-Hydroxy-5-methyl-2,3-dihydro-1H-inden-1-one収率 67.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
177.5 °C

実験手順

The mixture of 8-Methyl dihydrocoumarin (20 gm, 0.123 mole) and Aluminum trichloride (49.3 gm, 0.370 mole) was stirred for 2 hours at 175-180° C. To the reaction mixture, water (250 ml) was added slowly and stirred for an hour. Further it was filtered and obtained solid was stirred in Methanol (60 ml). Finally the suspension was filtered and obtained solid was dried under vacuum to give 13.5 gm of desired product as a solid.

後処理

  1. stirringstirred for an hour
  2. filtrationFurther it was filtered
  3. customobtained solid
  4. filtrationFinally the suspension was filtered
  5. customobtained solid
  6. customwas dried under vacuum

出典と根拠

ORDレコード
ord-315445d0dd5c4e439bf36c7c5047aa8d
出典データセット
uspto-grants-2013_02
特許番号
US08378118B2

反応ノート

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