Hydrogen Peroxide → 7-Methoxy-6-methyl-indan-4-ol
反応式
[CH3:1][O:2][C:3]1[C:11]2[CH2:10][CH2:9][CH2:8][C:7]=2[C:6](C=O)=[CH:5][C:4]=1[CH3:14].[OH:15]O>CO.S(=O)(=O)(O)O>[CH3:1][O:2][C:3]1[C:11]2[CH2:10][CH2:9][CH2:8][C:7]=2[C:6]([OH:15])=[CH:5][C:4]=1[CH3:14]参加物
5
反応条件
- 温度
- 0 °C
実験手順
The stirred solution of 7-methoxy-6-methyl-indan-4-carbaldehyde (1.0 gm, 0.0060 mole) in Methanol (20 ml), Sulphuric acid (0.6 ml) was added at room temperature. To the reaction mixture, 30% Hydrogen peroxide (1.6 ml) was added and stirred for 1 hour at 0° C. Methanol was distilled under vacuum and the residue was dissolved in Ethylacetate (50 ml), further ethyl acetate layer was washed with water and evaporated to give a crude product, which upon triturating with Hexane give 600 mg title compound as a solid.
後処理
- distillationMethanol was distilled under vacuum
- dissolutionthe residue was dissolved in Ethylacetate (50 ml)
- washfurther ethyl acetate layer was washed with water
- customevaporated
- customto give a crude product, which
- customupon triturating with Hexane
出典と根拠
- ORDレコード
- ord-7161538d91904e7d8b26b26c2a8d6a72
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08378118B2
反応ノート
読み込み中…