(2S,3R,4S,5R)-2,3,4,5-Tetrahydroxycyclohexanone → HCID 44511908、化合物

HRID 389373ノート

反応式

HRID 389373 の反応式
[CH2:1]1[C:6](=[O:7])[C@@H:5]([OH:8])[C@H:4]([OH:9])[C@@H:3]([OH:10])[C@@H:2]1O>O>[OH:10][C@@H:3]1[C@@H:4]([OH:9])[C@H:5]([OH:8])[C:6](=[O:7])[CH:1]=[CH:2]1

参加物

3

反応物 1

HCID 10583108(2S,3R,4S,5R)-2,3,4,5-Tetrahydroxycyclohexanone

生成物 1

HCID 44511908HCID 44511908、化合物収率 41.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.64 g of 2-deoxy-scyllo-inosose synthesized according to the method described in WO 2006/112000 and 5 mL of an ion exchange resin IR120B were added to 13.6 mL of water, and the resulting mixture was heated at reflux for 20 hours. After the completion of the reaction, the ion exchange resin was filtered and the filtrate was concentrated under a reduced pressure. The condensation residue was purified with silica gel column (ethyl acetate), whereby 604 mg (yield: 41%) of (4S,5R,6S)-4,5,6-trihydroxy-2-cyclohexene-1-one was obtained.

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureat reflux for 20 hours
  3. customAfter the completion of the reaction
  4. filtrationthe ion exchange resin was filtered
  5. concentrationthe filtrate was concentrated under a reduced pressure
  6. customThe condensation residue was purified with silica gel column (ethyl acetate)

出典と根拠

ORDレコード
ord-0b6e73355eb044b994887eabe1c841a7
出典データセット
uspto-grants-2013_02
特許番号
US08378146B2

反応ノート

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