Methylamine → HCID 85873295、化合物

HRID 389576ノート

反応式

HRID 389576 の反応式
[Br:1][C:2]1[C:10]2[S:9][C:8](Cl)=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:12][NH2:13]>>[Br:1][C:2]1[C:10]2[S:9][C:8]([NH:13][CH3:12])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 6329MethylamineHCID 667605757-BroMo-2-chlorobenzothiazole

生成物 1

HCID 85873295HCID 85873295、化合物収率 67.7%

反応条件

温度
60 °C

実験手順

7-Bromo-2-chlorobenzothiazole (85 mg, 0.34 mmol) and methylamine (2 M in THF, 3 mL, 6 mmol) were mixed and heated to 60° C. overnight. The solvent was evaporated. The residue was purified by ISCO chromatography (0 to 30% EtOAc:heptane) to afford 56 mg (67%) of the title compound. MS (ESI): 243.30, 245.26 [M+H]+; HPLC tR=1.09 min (HPLC: Anayltical—2 min).

後処理

  1. customThe solvent was evaporated
  2. customThe residue was purified by ISCO chromatography (0 to 30% EtOAc:heptane)

出典と根拠

ORDレコード
ord-f1b015357b124e8792248a6824282a77
出典データセット
uspto-grants-2013_02
特許番号
US08378104B2

反応ノート

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