Dimethylamine → HCID 66760220、化合物

反応式

[Br:1][C:2]1[C:10]2[S:9][C:8](Cl)=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:12][NH:13][CH3:14]>>[Br:1][C:2]1[C:10]2[S:9][C:8]([N:13]([CH3:14])[CH3:12])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 674Dimethylamine

HCID 667605757-BroMo-2-chlorobenzothiazole

生成物 1

HCID 66760220HCID 66760220、化合物収率 98.2%

反応条件

温度: 70 °C

実験手順

7-Bromo-2-chlorobenzothiazole (100 mg, 0.40 mmol) was added to dimethylamine (2.0 M in MeOH, 1 mL, 2 mmol) and the solution was heated at 70° C. for 1 h. The crude mixture was purified by ISCO chromatography (100% DCM) to afford 101 mg (98%) of the title compound as white solid. MS (ESI): 257.33, 259.36 [M+H]+; HPLC tR=1.40 min (HPLC: Anayltical—2 min).

後処理

customThe crude mixture was purified by ISCO chromatography (100% DCM)

出典と根拠

ORDレコード: ord-5e9a9f2b458341adb89143c9c459d3cf
出典データセット: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08378104B2

反応ノート

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