2-Piperidone → 1-(3-Benzylsulfanyl-2-trifluoromethyl-phenyl)piperidin-2-one

反応式

[CH2:1]([S:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11](Br)[C:10]=1[C:16]([F:19])([F:18])[F:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][C:21]1=[O:26]>>[CH2:1]([S:8][C:9]1[C:10]([C:16]([F:19])([F:18])[F:17])=[C:11]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][C:21]2=[O:26])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 126652-Piperidone

HCID 671552591-Benzylsulfanyl-3-bromo-2-trifluoromethyl-benzene

生成物 1

HCID 671555011-(3-Benzylsulfanyl-2-trifluoromethyl-phenyl)piperidin-2-one

実験手順

Intermediate 24 (10.5 g, 30.24 mmol) was coupled with piperidin-2-one (3.597 g, 36.29 mmol) in close analogy to the procedure described in step 1.6). After workup the crude oil is purified by chromatography on silica gel (n-heptane-ethyl acetate 4:1).

後処理

customis purified by chromatography on silica gel (n-heptane-ethyl acetate 4:1)

出典と根拠

ORDレコード: ord-daad2dec2bdb4c1e8ff7dba84cf6f138
出典データセット: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08378092B2

反応ノート

読み込み中…