4-(2-Methyl-thiazol-4-yl)-benzenesulfonyl chloride → HCID 67155481、化合物
反応式
Cl.Cl.[NH2:3][C@H:4]([C:15]([N:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)=[O:16])[CH2:5][NH:6][C:7]([C:9]1[S:10][C:11]([Cl:14])=[CH:12][CH:13]=1)=[O:8].[CH3:24][C:25]1[S:26][CH:27]=[C:28]([C:30]2[CH:35]=[CH:34][C:33]([S:36](Cl)(=[O:38])=[O:37])=[CH:32][CH:31]=2)[N:29]=1>C(Cl)Cl>[ClH:14].[CH3:23][N:20]1[CH2:19][CH2:18][N:17]([C:15](=[O:16])[C@@H:4]([NH:3][S:36]([C:33]2[CH:34]=[CH:35][C:30]([C:28]3[N:29]=[C:25]([CH3:24])[S:26][CH:27]=3)=[CH:31][CH:32]=2)(=[O:37])=[O:38])[CH2:5][NH:6][C:7]([C:9]2[S:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[O:8])[CH2:22][CH2:21]1参加物
4
実験手順
Intermediate 90 (0.2 g, 0.5 mmol) was dissolved in 10 ml DCM and TEA (0.35 ml, 2.5 mmol). Commercially available 4-(2-Methyl-thiazol-4-yl)-benzenesulfonyl chloride (130 mg, 0.47 mmol) in 5 ml DCM was slowly added at 0° C. and the reaction was stirred for 16 h. Then the solution was evaporated to dryness and purified by silica gel chromatography. The compound was dissolved in DCM, HCl (2 M in diethyl ether (500 ml)) was added and the solvents were evaporated to dryness.