反応式
C([NH:8][C@@H:9]([CH2:13][C:14]1[CH:21]=[C:19]([OH:20])[C:17]([OH:18])=[CH:16][CH:15]=1)[C:10]([OH:12])=[O:11])(OC(C)(C)C)=O.C1C=CC2N(O)N=NC=2C=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(CC)CC>C(Cl)Cl.CN(C=O)C.C(OCC)C>[O:11]=[C:10]([C@H:9]([CH2:13][C:14]1[CH:21]=[C:19]([OH:20])[C:17]([OH:18])=[CH:16][CH:15]=1)[NH2:8])[OH:12]参加物
8
反応物 4
生成物 1
試薬・触媒・溶媒 3
実験手順
2.1 g of p(EG1k-Asp) (1.77 mmol —NH2) was dissolved in 30 mL of DCM and 15 mL of DMF. 842 mg of N-Boc-DOPA (2.83 mmol), 382 mg of HOBt (2.83 mmol), HBTU (2.83 mmol), and 595 μL of Et3N (4.25 mmol) were added. The mixture was stirred for 1 hr at room temperature and added to 450 mL ethyl ether. The polymer was further precipitated in cold MeOH and dried in vacuum to yield 1.9 g of PEE-1 (GPC: Mw=33,800, PD=1.3; UV-vis: 7.7±1.3 wt % DOPA).
後処理
- customThe polymer was further precipitated in cold MeOH
- customdried in vacuum
出典と根拠
- ORDレコード
- ord-e2321beafadf4242989305f3aace3add
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383092B2
関連ノート
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