Pentane → HCID 67080890、化合物

HRID 389834ノート

反応式

HRID 389834 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]3OC(=O)[S:13][N:12]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[S:17]([C:27]#[N:28])([C:20]1[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=1)(=[O:19])=[O:18].CCCCC>ClC1C=CC=CC=1Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]3[N:28]=[C:27]([S:17]([C:20]4[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=4)(=[O:19])=[O:18])[S:13][N:12]=3)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 8003PentaneHCID 87946p-Toluenesulphonyl cyanideHCID 672348475-[1-(4-Chlorophenyl)cyclopropyl]-1,3,4-oxathiazol-2-one

生成物 1

HCID 67080890HCID 67080890、化合物収率 83.5%

試薬・触媒・溶媒 1

HCID 72391,2-Dichlorobenzene溶媒

実験手順

5.00 g (19.71 mmol) of 5-[1-(4-chlorophenyl)cyclopropyl]-1,3,4-oxathiazol-2-one and 3.75 g (20.69 mmol) of tosyl cyanide are stirred in 14 ml of 1,2-dichlorobenzene at 160° C. for 1 h. Subsequently, the reaction mixture is cooled, 10 ml of pentane are added and the precipitate is filtered off and dried under vacuum. 6.43 g of product are obtained (86.7% purity, 72.3% yield; log P (pH2.3)=4.97).

後処理

  1. temperatureSubsequently, the reaction mixture is cooled
  2. filtrationthe precipitate is filtered off
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-5143f2d42a6b42d08af9719c783ce270
出典データセット
uspto-grants-2013_02
特許番号
US08383139B2

反応ノート

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