化工社化工社 化学情報印刷レポート · 研究参考用
Water → (7-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Bromo-2-(oxiran-2-ylmethoxy)phenyl formate | HCID 21221027 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | (7-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol | HCID 233965 | 91.4% |
反応手順
5-bromo-2-(oxiran-2-ylmethoxy)phenyl formate (12.6 g, 46.0 mmol) was dissolved in dioxane (50 ml) and KOH (10%)/NaOH (20%) was added. Water and EtOAc was added and the phases were separated. The combined organic phases were washed with brine and dried to give the title compound (10.3 g). MS m/z (rel. intensity, 70 eV) 245 (M+, 96) 244 (M+, bp), 213 (29), 189 (46), 188 (49).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524766B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-917c12866a614ba8a573eedb3e45be44 |
| 出典メモ | uspto-grants-2013_09 |