化工社化工社 化学情報印刷レポート · 研究参考用
3-Methylacetophenone → 2-Bromo-1-(3-methylphenyl)ethan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methylacetophenone | HCID 11455 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-Bromo-1-(3-methylphenyl)ethan-1-one | HCID 10036129 | — |
反応手順
To a solution of 1-(3-methylphenyl)ethanone (2 g) in ethyl ether (20 mL) is added bromine (726 μL) at 0° C. The mixture is treated with an aqueous solution of sodium bicarbonate, extracted with ethyl ether, dried over magnesium sulfate, concentrated and purified on silica gel (ethyl acetate/cyclohexane 0/100) to give the desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383608B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-6dd5181a9b7a47fb8fad3019836c489d |
| 出典メモ | uspto-grants-2013_02 |