Triethylamine → 2-bromo-N-(pyrazin-2-yl)acetamide
反応式
[NH2:1][C:2]1[CH:6]=CN[N:3]=1.C([N:9]([CH2:12][CH3:13])CC)C.[Br:14][CH2:15][C:16](Cl)=[O:17]>CC(C)=O>[Br:14][CH2:15][C:16]([NH:1][C:2]1[CH:6]=[N:9][CH:12]=[CH:13][N:3]=1)=[O:17]参加物
5
反応条件
- 温度
- 2.5 °C
実験手順
A stirred solution of amino pyrazole (10 g, 105 mmol) in acetone (100 ml) is treated with triethylamine (16.1 ml, 115 mmol) and then cooled to 0-5° C. using an ice bath. To the cooled solution is added drop-wise bromoacetyl chloride (8.76 g, 105 mmol) in acetone (10 ml). The cooled reaction mixture is stirred for 3 hours and then filtered. The solvent is removed in vacuo and purification by chromatography on silica (eluting with ethyl acetate-iso-hexane, 2:1 increasing to 100% ethyl acetate) affords the titled compound.
後処理
- customThe cooled reaction mixture
- filtrationfiltered
- customThe solvent is removed in vacuo and purification by chromatography on silica (eluting with ethyl acetate-iso-hexane, 2:1 increasing to 100% ethyl acetate)
出典と根拠
- ORDレコード
- ord-b3fea9a964e045e2a2a95b3bbfb05a46
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383625B2
反応ノート
読み込み中…