化工社化工社 化学情報印刷レポート · 研究参考用
Water → (7-Bromo-5-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Potassium hydroxide monohydrate | HCID 23719240 | — |
| 反応物 | 5-Bromo-3-fluoro-2-(oxiran-2-ylmethoxy)phenyl acetate | HCID 86652944 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | (7-Bromo-5-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl)methanol | HCID 66878254 | 35% |
反応手順
5-bromo-3-fluoro-2-(oxiran-2-ylmethoxy)phenyl acetate (2.6 g, 8.7 mmol) was stirred in dioxane at RT. Aqueous KOH (10%) was added until basic pH was reached (1:1 water/KOH (10%)). Water was added and the solution was extracted with EtOAc: The combined organic phases were washed with brine, dried and evaporated to dryness to give the title compound (0.8 g). MS m/z (rel. intensity, 70 eV) 263 (M+, 97), 262 (M+, bp), 218 (39), 207 (50), 206 (51).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524766B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-debd2a7d3a8e4bb0a2c4384046cb343e |
| 出典メモ | uspto-grants-2013_09 |