化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Succinate → Cetirizine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Succinate | HCID 9020 | — |
| 反応物 | Cetirizine Hydrochloride | HCID 55182 | — |
| 反応物 | beta-Cyclodextrin | HCID 444041 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Cetirizine | HCID 2678 | — |
反応手順
A 65 L TK Fielder high sheer granulator equipped with a chopper is used for high shear granulation. The Cetirizine Dihydrochloride, Beta-cyclodextrin, PVP and Sodium Succinate are charged into the granulator and mixed for approximately 1 minute while with the chopper active. 1000 g of purified water is slowly added over 2 minutes while mixing and with the chopper active. The Corn Starch is then added and allowed to mix for 1 minute. The granulation is then dried in a Glatt GCPG 15 kg drying unit to a final LOD of approximately 7%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383632B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-6dbe8361c7384464b9416527f2839390 |
| 出典メモ | uspto-grants-2013_02 |