2-cyano-N-cyclohexyl-N-methylacetamide → 3-Amino-N-cyclohexyl-N-methyl-propionamide

HRID 390194ノート

反応式

HRID 390194 の反応式
[C:1]([CH2:3][C:4]([N:6]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH3:7])=[O:5])#[N:2].[H][H]>[Ni].N.CO>[NH2:2][CH2:1][CH2:3][C:4]([N:6]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH3:7])=[O:5]

参加物

5

反応物 2

HCID 247058332-cyano-N-cyclohexyl-N-methylacetamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 167934313-Amino-N-cyclohexyl-N-methyl-propionamide

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 21705897Ammonia methanol溶媒

実験手順

A mixture of 2-cyano-N-cyclohexyl-N-methyl-acetamide (3.96 g, 0.022 mol), a known compound, (which may be prepared as disclosed in Osdene, Thomas S. et al. Journal of Medicinal Chemistry (1967), 10(2), 165-7; Osdene, Thomas S.; Santilli, Arthur A. U.S. Pat. No. 3,138,595) and Raney nickel (3 g) in NH3/MeOH (300 mL) was hydrogenated at normal pressure. After 2 equivalents of hydrogen were consumed, the catalyst was removed by filtration. The filtrate was evaporated, and toluene was added to the residue and then evaporated to yield a residue.

後処理

  1. customa known compound, (which may be prepared
  2. customthe catalyst was removed by filtration
  3. customThe filtrate was evaporated
  4. additiontoluene was added to the residue
  5. customevaporated
  6. customto yield a residue

出典と根拠

ORDレコード
ord-0bf6a6dd20ba4f1b935acb9e65d733d7
出典データセット
uspto-grants-2013_02
特許番号
US08383637B2

反応ノート

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