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Ammonia → 3,5-Di(pyridin-3-yl)isoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 3-Ethynylpyridine | HCID 186003 | — |
| 反応物 | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| 生成物 | 3,5-Di(pyridin-3-yl)isoxazole | HCID 14593332 | — |
反応手順
The titled compound was prepared as the bishydrochloride salt according to Method CA using the product of Example 1A (0.78 g, 5.0 mmol) and 3-ethynylpyridine (Aldrich, 0.52 g, 5.0 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.76 (dd, J=8.1, 5.1 Hz, 1H), 7.79-7.86 (m, 1H), 7.98 (s, 1H), 8.44 (dt, J=8.0, 2.0, 1.9 Hz, 1H), 8.55 (dt, J=8.1, 1.9 Hz, 1H), 8.80 (dd, J=4.9, 1.5 Hz, 1H), 8.86 (dd, J=5.1, 1.7 Hz, 1H), 9.21 (d, J=2.0 Hz, 1H), 9.23 (d, J=2.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 224 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383658B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-7f076c8828724b3492713981d2642f36 |
| 出典メモ | uspto-grants-2013_02 |