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Ammonia → 4-(3-(Pyridin-3-yl)isoxazol-5-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 4-Ethynylbenzonitrile | HCID 4547245 | — |
| 反応物 | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| 生成物 | 4-(3-(Pyridin-3-yl)isoxazol-5-yl)benzonitrile | HCID 44546161 | — |
反応手順
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 4-ethynylbenzonitrile (Aldrich, 64 mg, 0.6 mmol). 1H NMR (300 MHz, DMSO-d6) δ7.69 (dd, J=8.0, 4.9 Hz, 2H), 7.96 (s, 1H), 8.03-8.20 (m, 3H), 8.39 (d, J=7.8 Hz, 1H), 8.78 (dd, J=4.7, 1.7 Hz, 1H), 9.16 (d, J=2.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 248 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383658B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-8977febfb27f4ca9ba0611657e6477a3 |
| 出典メモ | uspto-grants-2013_02 |