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Ammonia → 3-(Pyridin-3-yl)-5-(3-(trifluoromethyl)phenyl)isoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 1-Ethynyl-3-(trifluoromethyl)benzene | HCID 2778490 | — |
| 反応物 | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| 生成物 | 3-(Pyridin-3-yl)-5-(3-(trifluoromethyl)phenyl)isoxazole | HCID 44546222 | — |
反応手順
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-3-(trifluoromethyl)benzene (Aldrich, 85 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.64-7.76 (m, 1H), 7.81-7.96 (m, 2H), 7.98 (s, 1H), 8.20-8.30 (m, 2H), 8.41 (dt, J=8.1, 1.9 Hz, 1H), 8.79 (dd, J=4.8, 1.6 Hz, 1H), 9.17 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 291 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383658B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-ad2076865cf54acaac27e372b4041366 |
| 出典メモ | uspto-grants-2013_02 |