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Ammonia → 5-(3-Fluorophenyl)-3-(pyridin-3-yl)isoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 1-Ethynyl-3-fluorobenzene | HCID 520218 | — |
| 反応物 | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| 生成物 | 5-(3-Fluorophenyl)-3-(pyridin-3-yl)isoxazole | HCID 44546223 | — |
反応手順
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-3-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.35-7.51 (m, 1H), 7.60-7.82 (m, 4H), 7.84 (s, 1H), 8.42 (dt, J=8.1, 1.7 Hz, 1H), 8.80 (dd, J=5.0, 1.4 Hz, 1H), 9.17 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 241 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383658B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-c9dd3195296b4b4a85420eb9e3c68bec |
| 出典メモ | uspto-grants-2013_02 |