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Ammonia → 3-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 3-Ethynylbenzonitrile | HCID 12088964 | — |
| 反応物 | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| 生成物 | 3-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile | HCID 44546287 | — |
反応手順
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and the product of Example 19A (64 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.55 (s, 1H), 7.75 (t, J=7.9 Hz, 1H), 7.88 (dt, J=7.9, 1.4 Hz, 1H), 8.18 (ddd, J=9.3, 2.8, 1.8 Hz, 1H), 8.23 (ddd, J=7.9, 2.0, 1.2 Hz, 1H), 8.31 (t, J=1.6 Hz, 1H), 8.62 (d, J=2.8 Hz, 1H), 8.98 (t, J=1.6 Hz, 1 H) ppm; MS (DCI/NH3) m/z 266 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383658B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-44d5ca19e8cc4beea375f60dd735de39 |
| 出典メモ | uspto-grants-2013_02 |