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Ammonia → 4-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 4-Ethynylbenzonitrile | HCID 4547245 | — |
| 反応物 | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| 生成物 | 4-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile | HCID 44546290 | — |
反応手順
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 4-ethynylbenzonitrile (Aldrich, 64 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) 87.60 (s, 1H), 7.92 (dt, J=8.6, 1.7 Hz, 2H), 8.11 (dt, J=8.6, 1.7 Hz, 2H), 8.19 (ddd, J=9.2, 2.7, 1.7 Hz, 1H), 8.62 (d, J=2.7 Hz, 1H), 8.98 (t, J=1.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 266 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383658B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-bce0718a84594e818124aa4416dfa983 |
| 出典メモ | uspto-grants-2013_02 |