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Ammonia → 5-(3,4-Dichlorophenyl)-3-(5-fluoropyridin-3-yl)isoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 3,4-Dichlorophenylacetylene | HCID 44119622 | — |
| 反応物 | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| 生成物 | 5-(3,4-Dichlorophenyl)-3-(5-fluoropyridin-3-yl)isoxazole | HCID 44546348 | — |
反応手順
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 1,2-dichloro-4-ethynylbenzene (Aldrich, 86 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.50 (s, 1H), 7.72 (d, J=8.3 Hz 1H), 7.86 (dd, J=8.3, 1.9 Hz 1H), 8.12 (d, J=2.0 Hz, 1H), 8.17 (ddd, J=9.1, 2.8, 1.6 Hz, 1H), 8.62 (d, J=2.8 Hz, 1H), 8.97 (t, J=1.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 311 (M+H)+, 309 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383658B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-a57b0fc030104499b49035af8343b933 |
| 出典メモ | uspto-grants-2013_02 |