Ammonia → 3-(3-(Pyrazin-2-yl)isoxazol-5-yl)benzonitrile

関与物質

役割	名称	HCID	仕込み量
反応物	Ammonia	HCID 222	—
反応物	3-Ethynylbenzonitrile	HCID 12088964	—
反応物	N-Hydroxypyrazine-2-carbimidoyl chloride	HCID 136395910	—
生成物	3-(3-(Pyrazin-2-yl)isoxazol-5-yl)benzonitrile	HCID 44545616	—

反応手順

The titled compound was prepared according to Method CB using the product of Example 83D (79 mg, 0.5 mmol) and the product of Example 19A (64 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.59 (s, 1H), 7.75 (t, J=8.1 Hz, 1H), 7.88 (dt, J=8.0, 1.4, 1.2 Hz, 1H), 8.21-8.30 (m, 1H), 8.31-8.37 (m, 1H), 8.71 (d, J=2.7 Hz, 1H), 8.77 (dd, J=2.5, 1.5 Hz, 1H), 9.31 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 249 (M+H)+.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08383658B2
出典データセット	uspto-grants-2013_02
ORD ID	ord-39ba24d52ad3487ba3e3c80508a3c58c
出典メモ	uspto-grants-2013_02