Ammonia → 5-(3-Chlorophenyl)-3-(pyrazin-2-yl)isoxazole

関与物質

役割	名称	HCID	仕込み量
反応物	Ammonia	HCID 222	—
反応物	1-Chloro-3-ethynylbenzene	HCID 123086	—
反応物	N-Hydroxypyrazine-2-carbimidoyl chloride	HCID 136395910	—
生成物	5-(3-Chlorophenyl)-3-(pyrazin-2-yl)isoxazole	HCID 44545617	—

反応手順

The titled compound was prepared according to Method CB using the product of Example 83D (79 mg, 0.5 mmol) and 1-chloro-3-ethynylbenzene (Apollo, 68 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ7.49 (s, 1H), 7.51-7.59 (m, 2 H), 7.85-7.91 (m, 1H), 7.94-8.04 (m, 1H), 8.70 (d, J=2.4 Hz, 1H), 8.76 (dd, J=2.5, 1.5 Hz, 1H), 9.30 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 258 (M+H)+, 260 (M+H)+.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08383658B2
出典データセット	uspto-grants-2013_02
ORD ID	ord-f9bdeae5700b4c3b9522e678249fa793
出典メモ	uspto-grants-2013_02