(6-Iodopyridin-3-yl)methanol → 6-Iodopyridine-3-carbaldehyde

HRID 390596ノート

反応式

HRID 390596 の反応式
[I:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+2]>[I:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 23039516(6-Iodopyridin-3-yl)methanol

生成物 1

HCID 534852236-Iodopyridine-3-carbaldehyde収率 74%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒HCID 6344Dichloromethane溶媒

実験手順

86 g (987 mol) of manganese (II) oxide are added to a solution of 23.2 g (98.7 mmol) of (6-iodopyrid-3-yl)methanol in 800 mL of dichloromethane. The reaction mixture is stirred at room temperature for 22 hours. The reaction mixture is filtered through Celite and rinsed with dichloromethane. The filtrate is evaporated under vacuum to give 17 g (74%) of 6-iodopyridine-3-carbaldehyde in the form of a yellow solid.

後処理

  1. filtrationThe reaction mixture is filtered through Celite
  2. washrinsed with dichloromethane
  3. customThe filtrate is evaporated under vacuum

出典と根拠

ORDレコード
ord-59f54983381a4a138629797dbf0435ea
出典データセット
uspto-grants-2013_02
特許番号
US08383652B2

反応ノート

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