Hydrochloric Acid → HCID 16225331、化合物
反応式
[ClH:1].[CH2:2]([O:4]/[C:5](=[CH:9]\[C:10]1[CH:11]=[N:12][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N:22]([CH3:33])[C:23]([NH:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:24])[CH:17]=2)=[CH:14][CH:15]=1)/[C:6]([OH:8])=[O:7])[CH3:3]>C(O)C>[ClH:1].[CH2:2]([O:4]/[C:5](=[CH:9]\[C:10]1[CH:11]=[N:12][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N:22]([CH3:33])[C:23]([NH:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:24])[CH:17]=2)=[CH:14][CH:15]=1)/[C:6]([OH:8])=[O:7])[CH3:3]参加物
4
実験手順
0.3 mL (0.3 mmol) of a 1 N ethanolic hydrogen chloride solution is added to a solution of 0.12 g (0.3 mmol) of (Z)-2-ethoxy-3-{6-[3-(3-heptyl-1-methylureido)phenyl]pyrid-3-yl}acrylic acid in 1 mL of ethanol, precooled to 0° C. The ethanol is evaporated off under a flow of nitrogen and 6 mL of diethyl ether are added. The hydrochloride precipitates; the reaction medium is filtered off and the solid obtained is rinsed thoroughly with diethyl ether. The solid obtained is recrystallized from a hot mixture of acetone and a minimum amount of water. 100 mg (77%) of (Z)-2-ethoxy-3-{6-[3-(3-heptyl-1-methylureido)phenyl]pyrid-3-yl}acrylic acid hydrochloride are obtained in the form of a yellow solid with a melting point of 170° C.