Triethyl phosphite → Methyl (diethoxyphosphoryl)methoxyacetate

反応式

Cl[CH2:2][O:3][CH2:4][C:5]([O:7][CH3:8])=[O:6].[P:9]([O:16]CC)([O:13][CH2:14][CH3:15])[O:10][CH2:11][CH3:12]>>[CH2:11]([O:10][P:9]([CH2:2][O:3][CH2:4][C:5]([O:7][CH3:8])=[O:6])([O:13][CH2:14][CH3:15])=[O:16])[CH3:12]

参加物

反応物 2

HCID 31215Triethyl phosphite

HCID 22034352Methyl chloromethoxyacetate

生成物 1

HCID 85679938Methyl (diethoxyphosphoryl)methoxyacetate収率 100.7%

反応条件

温度: 150 °C

実験手順

26 g (186 mmol) of methyl chloromethoxyacetate and 32 mL (186 mmol) of triethyl phosphite are placed in a round-bottomed flask and heated at 150° C. for 3 hours. The reaction progress is monitored by NMR. The reaction medium is concentrated under vacuum. 45 g (100%) of methyl (diethoxyphosphoryl)methoxyacetate are obtained directly in the form of a colorless liquid.

後処理

concentrationThe reaction medium is concentrated under vacuum

出典と根拠

ORDレコード: ord-f763b70300064a05a1b402dc1807d717
出典データセット: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08383652B2

反応ノート

読み込み中…