1,1'-Carbonyldiimidazole → (NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]imidazole-1-carboxamide

関与物質

反応手順

(2Z)-3-(4-Chlorophenyl)-1,3-thiazolidin-2-imine (233 mg, 1.095 mmol, Example 24A) and carbonyldiimidazole (195 mg, 1.205 mmol) in dry tetrahydrofuran were heated at 65° C. After 14 hours the reaction mixture cooled down, diluted with 75 mL of dichloromethane, and washed successively with sodium bicarbonate (50 mL) water and brine (50 mL), dried over magnesium sulfate and concentrated under reduced pressure to give the title compound.

情報源と証拠