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Methyl iodide → (NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]-3-methylimidazol-3-ium-1-carboxamide iodide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | (NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]imidazole-1-carboxamide | HCID 87449094 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]-3-methylimidazol-3-ium-1-carboxamide iodide | HCID 87447829 | — |
反応手順
N-[(2Z)-3-(4-Chlorophenyl)-1,3-thiazolidin-2-ylidene]-1H-imidazole-1-carboxamide (320 mg, 1.043 mmol, Example 25A) was suspended in dry acetonitrile (5 mL), and then iodomethane (0.325 mL, 5.22 mmol) was added. The mixture stirred at room temperature. After four days, the solvent was evaporated to give the title product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383657B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-9fa71b9d1bd841759cde32862025345d |
| 出典メモ | uspto-grants-2013_02 |