Morpholine → 2-Chloro-4-morpholinofuro[3,2-d]pyrimidine

HRID 390813ノート

反応式

HRID 390813 の反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[O:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>CO>[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[O:10][CH:9]=[CH:8][C:6]=2[N:7]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 457899682,4-Dichlorofuro[3,2-D]pyrimidine

生成物 1

HCID 568337412-Chloro-4-morpholinofuro[3,2-d]pyrimidine収率 48%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2,4-Dichlorofuro[3,2-d]pyrimidine 37 (23 mg, 1.0 eq) was suspended in methanol (1.7 ml) and treated with morpholine (0.09 ml, 4.0 eq). Reaction mixture was stirred at room temperature for 2 h, before being quenched with saturated aq. NaHCO3. Mixture was extracted with dichloromethane. The combined organic layers were dried (Na2SO4) and concentrated to yield 2-chloro-4-morpholinofuro[3,2-d]pyrimidine 38 (14 mg, 48%) which was used in the next reaction without further purification.

後処理

  1. customReaction mixture
  2. custombefore being quenched with saturated aq. NaHCO3
  3. extractionMixture was extracted with dichloromethane
  4. dry with materialThe combined organic layers were dried (Na2SO4)
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-af65e09f594f4e208c058c8d92086afc
出典データセット
uspto-grants-2013_02
特許番号
US08383620B2

反応ノート

読み込み中…