Hydrochloric Acid → 1-(Thiophene-2-sulfonyl)piperazine hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CO.ClCCl.C(OCC)C>[ClH:22].[S:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[S:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)(=[O:16])=[O:15]参加物
6
実験手順
4-(2-Thiophenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (759 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (11.4 ml) was added and the reaction mixture was stirred at room temperature overnight, then cooled in ice bath, the resulted precipitate was filtered, washed with ether to yield 4-(2-thiophenesulfonyl)-piperazine hydrochloride salt (529 mg).
後処理
- temperaturecooled in ice bath
- filtrationthe resulted precipitate was filtered
- washwashed with ether
出典と根拠
- ORDレコード
- ord-9b0aa01a386e49b6b194060d6771ce59
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383620B2
反応ノート
読み込み中…