Hydrochloric Acid → 1-(4-Fluorobenzenesulfonyl)piperazine hydrochloride

HRID 390991ノート

反応式

HRID 390991 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.ClCCl.C(OCC)C>[ClH:24].[F:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:16])=[O:15])=[CH:22][CH:21]=1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 4634543HCID 4634543、化合物

生成物 1

HCID 173683141-(4-Fluorobenzenesulfonyl)piperazine hydrochloride

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

4-(4-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (937 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (13.6 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(4-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (819 mg).

後処理

  1. customVolatiles were removed in vacuo

出典と根拠

ORDレコード
ord-bba8de4c52164eee843962ab9e57b083
出典データセット
uspto-grants-2013_02
特許番号
US08383620B2

反応ノート

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